Genetic Variants as Sudden-Death Risk Markers in Inherited Arrhythmogenic Syndromes: Personalized Genetic Interpretation
نویسندگان
چکیده
منابع مشابه
Genetic Insurance Discrimination in Sudden Arrhythmia Death Syndromes
Sudden unexpected death is defined as a natural unexpected fatal event that occurs within 1 hour of the onset of symptoms in an apparently healthy subject or in one whose disease was not so severe as to predict such an abrupt outcome. Approximately 294 851 adults and 2000 children die of sudden unexpected death in the United States each year. Evidence from a Danish population suggests an incide...
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BACKGROUND Genome-wide association studies and candidate-gene based approaches have identified multiple common variants associated with increased risk of sudden cardiac death (SCD). However, the independent contribution of these individual loci to disease risk is modest. OBJECTIVE To investigate the cumulative effects of genetic variants previously associated with SCD risk. METHODS A total ...
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BACKGROUND Sympathetic activation influences the risk of ventricular arrhythmias and sudden cardiac death (SCD), mediated in part by the beta2-adrenergic receptor (B2AR). We investigated whether variation in the B2AR gene is associated with SCD risk. METHODS AND RESULTS In this study, 4441 white and 808 black Cardiovascular Health Study (CHS) participants were followed up prospectively for SC...
متن کاملPredicting sudden cardiac death using common genetic risk variants for coronary artery disease.
AIMS Genome-wide association studies (GWAS) have identified many variants associating with an increased risk of coronary artery disease (CAD). We studied the possible association between these variants and the risk of sudden cardiac death (SCD). METHODS AND RESULTS A weighted genetic risk score (GRSCAD) was formed from variants most strongly associating with CAD identified by the CARDIoGRAMpl...
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Background: Thrombophilia is a main predisposition to thrombosis due to a procoagulant state. Several point mutations play key roles in blood-clotting disorders, which are grouped under the term thrombophilia. These thrombophilic mutations are methylenetetrahydrofolate reductase (MTHFR, C677T, and A1298C), factor V Leiden (G1691A), prothrombin gene mutation (factor II, G20210A), and plasminogen...
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ژورنال
عنوان ژورنال: Journal of Clinical Medicine
سال: 2020
ISSN: 2077-0383
DOI: 10.3390/jcm9061866